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The GEC ESTRO Handbook of Brachytherapy: Radiation Protection in Brachytherapy (2nd edition - December 1, 2014)

Panagiotis Papagiannis , Jack Venselaar

This chapter aims to summarize technical and procedural information to aid the process of optimization of protection in brachytherapy, and to highlight some key elements of this process by elaborating on aspects of radiation protection in practice.

The GEC ESTRO Handbook of Brachytherapy: Prostate Cancer (2nd edition - December 1, 2014)

Peter Hoskin , György Kovacs , Marco van Vulpen , Dimos Baltas

Brachytherapy is now established as an effective treatment for prostate cancer alongside radical prostatectomy and external beam radiotherapy. The ultrasound guided transperineal approach has been developed to combine real time imaging of the implantation with one step dosimetry ensuring consistently high standards of implant quality which is related to outcome. Brachytherapy has the physical advantage of being able to concentrate a high radiation dose in the target with high conformality minimizing doses to organs at risk. HDR brachytherapy delivered in large doses per fraction also exploits the low alpha beta ratio of prostate cancer delivering very high equi-effective doses in excess of 100Gy (EQD2).

The GEC ESTRO Handbook of Brachytherapy - Rectal cancer (2nd edition - December 10, 2014)

Arthur Sun Myint , Chris D Lee , Jean Pierre Gerard

The concept of rectal cancer management has changed rapidly over the past few years. The standard of care in rectal cancer is still surgery. However, there is 

The GEC ESTRO Handbook of Brachytherapy: Urinary Bladder Cancer (2nd edition - May 1, 2015)

Bradley Pieters , Elzbieta van der Steen-Banasik , Erik Van Limbergen

Brachytherapy for bladder cancer was introduced several decades ago as a treatment to preserve bladder function. 

The GEC ESTRO Handbook of Brachytherapy: Radiobiology of LDR, HDR, PDR and VLDR Brachytherapy (2nd edition - November 12, 2015)

Erik Van Limbergen , Michael Joiner , Albert Van der Kogel , Wolfgang Dörr

Brachytherapy (BT) differs from external beam therapy (EBRT) in two main ways: the distribution of the absorbed dose and the time-dose patterns. 


The GEC ESTRO Handbook of Brachytherapy: Endometrial Cancer (2nd edition - April 28, 2016)

Peter Hoskin , Taran Paulsen Hellebust , Remi Nout , Ina Jϋrgenliemk-Schulz , Christine Haie-Meder , Erik Van Limbergen , Richard Pötter

Endometrial cancer presents in most women at an early stage confined to the uterus and initial treatment is by hysterectomy. Postoperative treatment is indicated for intermediate and high risk patients defined by age, stage, grade and the presence or absence of lymphovascular space invasion.

The GEC ESTRO Handbook of Brachytherapy: Bile Duct Cancer (2nd edition - April 30, 2017)

Janusz Skowronek

Biliary tract cancer is a rare disease. Surgical resection offers the best chance for long-term survival, but the results are not satisfactory and local relapses are frequent. The majority of patients present with locally advanced or metastatic disease, which is not amenable to surgical resection, resulting in poor survival [1]. Adjuvant or definitive radiotherapy (RT) with or without chemotherapy is therefore used in many centers worldwide for better local control and with the expectation that it will have a favorable effect on survival. However, the lack of appropriate prospective trials, as well as the small size of the published series and their retrospective nature, has produced insufficient evidence for the best treatment for these patients [1]. 

The GEC ESTRO Handbook of Brachytherapy - Skin cancer (2nd edition - May 03, 2017)

Jose Luis Guinot , Jose Pérez-Calatayud , Erik Van Limbergen

Non-melanoma skin cancer can be treated with brachytherapy as an alternative to surgery, with some advantages in dosimetry compared with external beam radiation due to the rapid fall-off of the dose. LDR is no longer available, and HDR looks for reproducing the good results achieved during decades. A standard optimal schedule for HDR is not well defined, and different options have been published. In superficial tumours, contact brachytherapy is simple and effective, with flaps, personalized moulds or surface applicators. The larger the area to be irradiated, the lower the dose should be per fraction. In carcinomas deeper than 5mm an interstitial technique with plastic tubes or needles is mandatory. 


The GEC ESTRO Handbook of Brachytherapy - Bronchus cancer (2nd edition - May 03, 2017)

Erik Van Limbergen , Janusz Skowronek , Richard Pötter

Brachytherapy is one of the most efficient methods in overcoming difficulties in breathing that is caused by endobronchial obstruction in palliative treatment of bronchus cancer. Depending on the location of the lesion in some cases brachytherapy is the treatment of choice often combined with a recanalisation procedure. Because of uncontrolled local or recurrent disease, patients may have significant symptoms such as: cough, dyspnea, hemoptysis, obstructive pneumonia or atelectasis. Efforts to relieve this obstructive process are worthwhile, because patients may experience improved quality of their life.

The GEC ESTRO Handbook of Brachytherapy - General Aspects of Head and Neck Brachytherapy (2nd edition - February 06, 2019)

Rafael Martínez-Monge , José Luis Guinot , Christine Haie-Meder

This chapter describes the general principles of head and neck brachytherapy with special emphasis on clinical indications, implantation techniques, brachytherapy modalities, treatment planning and reporting and patient care.

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